Markers of oxidative stress in dogs with heart failure
نویسندگان
چکیده
منابع مشابه
Oxidative stress and heart failure.
Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative to antioxidant defense, has been shown to play an important role in the pathophysiology of cardiac remodeling and heart failure (HF). It induces subtle changes in intracellular pathways, redox signaling, at lower levels, but causes cellular dysfunction and damage at higher levels. ROS are derived from se...
متن کاملInfluence of cardiac resynchronization therapy on oxidative stress markers in patients with chronic heart failure.
BACKGROUND The aim of the study was to assess changes of substances of oxidative stress in patients treated with cardiac resynchronization therapy (CRT). METHODS The study comprised 51 patients with median age of 66 years. The presence, severity, and changes of oxidative stress during CRT were assessed and expressed as malondialdehyde (MDA) concentration in plasma or in red blood cells. Antio...
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Oxidative stress contributes to various cardiovascular diseases and aging and was causally linked to the progression of heart failure (1,2). Among the most relevant sources for reactive oxygen species (ROS) are nicotinamide adenine dinucleotide phosphate (NADPH) oxidases and mitochondria (1,3–7). The ROS impair excitation-contraction coupling, cause arrhythmias, and contribute to cardiac remode...
متن کاملTargeting oxidative stress in heart failure
Increased oxidative stress is recognized to be important in the pathogenesis of cardiovascular disease, including heart failure. Reactive oxygen species (ROS) can be derived from diverse sources, including mitochondria, NADPH oxidase, and xanthine oxidase. Many agents established in the treatment of heart failure (including angiotensin-converting enzyme inhibitors, statins, b-blockers, hydralaz...
متن کاملIncreased oxidative stress in patients with congestive heart failure.
OBJECTIVES We sought to study the markers of lipid peroxidation and defenses against oxidative stress in patients with varying degrees of heart failure. BACKGROUND Despite advances in other areas of cardiovascular disease, the morbidity and mortality from congestive heart failure (CHF) are increasing. Data mainly from animal models suggest that free radical injury may promote myocardial decom...
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ژورنال
عنوان ژورنال: Journal of Veterinary Diagnostic Investigation
سال: 2017
ISSN: 1040-6387,1943-4936
DOI: 10.1177/1040638717711995